Drug intelligence / Profile preview

lactobacillus acidophilus + lactobacillus rhamnosus + lactobacillus gasseri + lactobacillus acidophilus NCFM + lactobacillus casei

Development stage
Unknown
Lead developer
International Flavors & Fragrances
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

This probiotic combination consists of five distinct Lactobacillus strains, including the well-characterized **Lactobacillus acidophilus NCFM** and **Lactobacillus gasseri**. The formulation is primarily designed to support gastrointestinal health, immune function, and metabolic wellness. **L. acidophilus NCFM** is notable for its ability to adhere to the human intestinal mucosa and its unique mechanism of inducing the expression of mu-opioid and cannabinoid receptors in the gut, which helps alleviate visceral pain and bloating associated with Irritable Bowel Syndrome (IBS). **Lactobacillus gasseri** is frequently studied for its role in metabolic health, specifically in reducing abdominal adiposity and supporting weight management. The inclusion of **L. rhamnosus** and **L. casei** provides broad-spectrum support by competing with pathogenic bacteria for adhesion sites, producing lactic acid to maintain a healthy luminal pH, and modulating the gut-associated lymphoid tissue (GALT) to enhance systemic immune responses. This specific blend is commonly marketed as a dietary supplement for digestive comfort and metabolic support.

Brand names
UltraFlora ControlUltraFlora SpectrumHOWARU ShapeHOWARU Balance
Other names
L. acidophilus + L. rhamnosus + L. gasseri + L. acidophilus NCFM + L. caseiProbiotic 5-strain blendProbiotic5-strain blendProbiotic-5-strain blendLactobacillus acidophilus NCFMLactobacillus gasseriLactobacillus rhamnosusLactobacillus casei
02

Targets

MOR (Mu opioid receptor)CB (Cannabinoid receptors)

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