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lactobacillus fermentum + lactobacillus paracasei
- Development stage
- Preclinical
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
A combination probiotic biologic consisting of heat-attenuated strains of *Lactobacillus fermentum* and *Lactobacillus paracasei*. [1] It is used to treat allergic disorders such as atopic dermatitis, allergic asthma, and allergic rhinitis. [1] The mechanism of action involves modulating the immune system's response to allergens. [1] It targets specific regions in the intestine, like Peyer's patches, regulates the production of inflammatory cytokines, and supports a healthy balance of gut microflora. [1] Clinical studies in children have demonstrated that this combination can reduce the severity of atopic dermatitis and asthma.
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