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lactobacillus rhamnosus GR-1 + lactobacillus reuteri RC-14
- Development stage
- Phase 3
- Lead developer
- Novonesis
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Intravaginal
01
Overview
Lactobacillus rhamnosus GR-1 + Lactobacillus reuteri RC-14 is a specific probiotic combination developed to support and restore the female urogenital microbiome. The two strains were originally isolated from the distal urethra and vagina of healthy women by researchers Gregor Reid and Andrew Bruce at Western University. *L. rhamnosus* GR-1 is known for its ability to colonize the vaginal tract and inhibit the adhesion of uropathogens, while *L. reuteri* RC-14 (formerly classified as *L. fermentum*) produces biosurfactants and hydrogen peroxide that disrupt pathogen biofilms. Together, they work by lowering vaginal pH through lactic acid production and competing with pathogenic bacteria such as *Gardnerella vaginalis*, *Escherichia coli*, and *Candida* species. The combination is widely used as an oral or vaginal intervention for bacterial vaginosis, yeast vaginitis, and the prevention of recurrent urinary tract infections.
- Brand names
- Vagi-GardOptiBac Probiotics For WomenBlackmores Probiotics Women's Flora Balance
- Other names
- Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14Lactobacillus rhamnosus GR-1 + Limosilactobacillus reuteri RC-14
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