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lactoperoxidase + thiocyanate + hydrogen peroxide
- Development stage
- Phase 1
- Lead developer
- Universitätsklinikum Greifswald
- Modality
- Therapeutic Enzymes → Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral
01
Overview
Lactoperoxidase + thiocyanate + hydrogen peroxide (LPO-system) is an enzymatic antimicrobial combination delivered in lozenge form for oral hygiene. The system mimics a naturally occurring physiological defense mechanism found in saliva. Lactoperoxidase catalyzes the oxidation of thiocyanate ions by hydrogen peroxide to generate hypothiocyanous acid (HOSCN), a potent antimicrobial agent that inhibits the growth of cariogenic bacteria and reduces dental plaque formation. It has been evaluated in Phase I clinical trials by researchers at the University Medicine Greifswald for the prevention of dental plaque and caries.
- Other names
- LPO-systemlactoperoxidase system
02
Targets
LPO (Lactoperoxidase)
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