lamivudine + zidovudine + nevirapine

Lamivudine + zidovudine + nevirapine is a fixed-dose combination antiretroviral medication used for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg. It contains two nucleoside analogue reverse transcriptase inhibitors (lamivudine and zidovudine) and one non-nucleoside reverse transcriptase inhibitor (nevirapine). Lamivudine and zidovudine inhibit HIV reverse transcription by causing viral DNA chain termination, while nevirapine binds directly to reverse transcriptase, causing a conformational change that inhibits its activity. This combination reduces the amount of virus in the body, increases CD4 cell counts, and slows disease progression. It is not curative but helps manage HIV infection[1][2][5][8].

Brand names

Duovir NLazid NVirocomb NZidolam N NZidovex LNTrezavNexvir ZN

Other names

lamivudine/nevirapine/zidovudine tablets