Drug intelligence / Profile preview

lanreotide + metformin

Development stage
Unknown
Modality
Peptides, Small Molecules
Administration
Subcutaneous, Oral
01

Overview

A combination therapy consisting of lanreotide, a somatostatin analog, and metformin, an antidiabetic medication. This combination has shown promising antitumor activity in both diabetic and non-diabetic patients with well-differentiated neuroendocrine tumors (WDNETs) of the gastrointestinal or thoracic tract. The MetNET-2 trial demonstrated that this combination is safe and well-tolerated with a median progression-free survival of 24 months.

Other names
Lanreotide and MetforminLanreotide 120 mg ATG + Metformin
02

Targets

ND1 (Mitochondrial electron transport chain complex I)AMPK (Adenosine monophosphate–activated protein kinase)SSTR5 (Somatostatin receptor 5)SSTR2 (Somatostatin receptor type 2)

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