lansoprazole + sodium bicarbonate

Lansoprazole + sodium bicarbonate is a fixed-dose combination oral pharmaceutical product consisting of the proton pump inhibitor (PPI) lansoprazole and the antacid sodium bicarbonate. Lansoprazole acts by irreversibly inhibiting the H+/K+-ATPase enzyme (proton pump) in gastric parietal cells, thereby suppressing gastric acid secretion. Sodium bicarbonate serves as an antacid that rapidly neutralizes stomach acid and protects lansoprazole from degradation in acidic conditions, allowing for faster absorption and onset of action compared to enteric-coated formulations. This combination is primarily indicated for peptic ulcer disease (gastric ulcer, duodenal ulcer), reflux esophagitis (GERD), anastomotic ulcers, and Zollinger-Ellison syndrome. Clinical studies show it achieves higher peak plasma concentrations more quickly than conventional enteric-coated lansoprazole capsules[1][2][5]. The safety profile is favorable with only mild adverse reactions reported[1][5].

Brand names

信维宁

Other names

兰索拉唑碳酸氢钠lansoprazole/sodium bicarbonate兰索拉唑碳酸氢钠胶囊