Drug intelligence / Profile preview

latanoprost + dorzolamide

Development stage
Phase 2
Lead developer
Pfizer
Modality
Small Molecules
Administration
Ophthalmic, Topical
01

Overview

Latanoprost + dorzolamide is a fixed-dose combination ophthalmic medication used to reduce elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Latanoprost is a prostaglandin F2 alpha analog that increases the outflow of aqueous humor, thereby lowering intraocular pressure. Dorzolamide is a carbonic anhydrase inhibitor that decreases aqueous humor production by inhibiting the enzyme carbonic anhydrase in the ciliary processes of the eye. The combination leverages complementary mechanisms to achieve greater intraocular pressure reduction than either agent alone, and it is typically administered as topical eye drops.

Other names
ALZ-1101ALZ1101ALZ 1101
02

Targets

CA2 (Carbonic Anhydrase 2)PTGFR (Prostaglandin F2 alpha receptor)

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