Drug intelligence / Profile preview

LBL-024 + docetaxel

Development stage
Unknown
Lead developer
LEADS BioLabs
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

**LBL-024 + docetaxel** is an investigational intravenous anticancer co-administration regimen being evaluated by Leads Biolabs in advanced non-small cell lung cancer. LBL-024 is a tetravalent PD-L1 × 4-1BB bispecific antibody designed to block PD-L1-mediated immune-checkpoint signaling while conditionally agonizing 4-1BB in the tumor microenvironment to enhance T-cell activation. Docetaxel is a taxane chemotherapy that binds tubulin, stabilizes microtubules, and inhibits mitosis. The regimen is being studied in a recruiting Phase 2 substudy of an advanced solid-tumor trial, including an LBL-024 plus docetaxel cohort for advanced non-small cell lung cancer.

Other names
docetaxel + LBL-024LBL 024 + docetaxelLBL024 + docetaxel
02

Targets

TNFRSF9 (CD137 extracellular domain)CD274 (Programmed cell death protein 1 ligand 1)Microtubule

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