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Drug intelligence / Profile preview
lemzoparlimab + azacitidine
- Development stage
- Phase 2
- Lead developer
- I-MAB
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
Lemzoparlimab + azacitidine is an investigational combination therapy for hematologic malignancies, particularly higher-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Lemzoparlimab is a novel humanized monoclonal antibody targeting CD47, a cell surface protein that delivers a "don't eat me" signal to macrophages. By blocking CD47, lemzoparlimab enables macrophage-mediated phagocytosis of leukemic cells. Azacitidine is a well-established hypomethylating agent used in the treatment of MDS and AML. The combination has demonstrated strong anti-leukemic activity in preclinical studies and early-phase clinical trials, with encouraging response rates and manageable safety profiles. Lemzoparlimab’s design aims to minimize binding to normal red blood cells, potentially reducing the risk of severe anemia compared to other anti-CD47 antibodies[1][2][5].
- Other names
- lemzoparlimab + azacitidine
02
Targets
CD47 (Cluster of Differentiation 47)DNMT (DNA methyltransferase)
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