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LEO 29102 + calcipotriol
- Development stage
- Unknown
- Lead developer
- LEO Pharma
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
LEO 29102 + calcipotriol is a topical combination therapy under investigation for the treatment of psoriasis and atopic dermatitis. LEO 29102 is a small molecule phosphodiesterase 4 (PDE4) inhibitor developed by Leo Pharma, designed to reduce inflammation by inhibiting PDE4 activity in immune cells[1][3][5]. Calcipotriol (also known as calcipotriene) is a synthetic vitamin D3 analog that modulates keratinocyte proliferation and differentiation, inhibits pro-inflammatory cytokine expression, and shifts T-cell responses from Th1/Th17 toward Th2/Treg phenotypes[2][6][8]. The combination aims to leverage the complementary anti-inflammatory and immunomodulatory effects of both agents for enhanced efficacy in plaque psoriasis.
- Brand names
- DovonexCalcitreneDovobetEnstilarSoriluxTaclonexWynzora
- Other names
- calcipotriene
02
Targets
PDE4 (Phosphodiesterase 4A1)VDR (Vitamin D receptor)
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