leukocyte-rich platelet-rich plasma (Clinical Center of Vojvodina)

Leukocyte-rich platelet-rich plasma (LR-PRP) is an autologous blood-derived biologic therapy characterized by a high concentration of platelets and leukocytes compared to baseline whole blood. In the clinical context of the Clinical Center of Vojvodina, it is prepared using a double-spinning process (e.g., via the Arthrex Angel Centrifuge) to concentrate growth factors and immune cells from a patient's own blood. The therapeutic rationale for its use in knee osteoarthritis lies in the release of bioactive proteins from platelet alpha-granules, such as PDGF, TGF-β, and VEGF, which promote tissue repair, modulate the intra-articular inflammatory environment, and stimulate chondrocyte proliferation. The inclusion of leukocytes is intended to provide additional signaling molecules and potentially enhance the regenerative response, although their specific role in joint inflammation remains a subject of clinical investigation.

Other names

LR-PRPLeukocyte-Rich PRPLeukocyte-Rich Platelet-Rich Plasma