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Drug intelligence / Profile preview
leuprorelin (Takeda)
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Peptides
- Administration
- Subcutaneous, Intramuscular
01
Overview
Enantone-Gyn Monats-Depot is a monthly depot formulation of leuprorelin acetate, a synthetic gonadotropin-releasing hormone (GnRH) agonist. It acts by initially stimulating but subsequently desensitizing the pituitary GnRH receptors, leading to a profound suppression of gonadotropin (LH and FSH) secretion and a consequent reduction in sex hormone (estrogen and testosterone) levels. Developed by Takeda, this sustained-release microcapsule formulation is administered via subcutaneous or intramuscular injection. It is primarily indicated for the treatment of endometriosis, uterine fibroids (myomas), and hormone-dependent breast cancer. In clinical research, such as the GARTE Phase 4 trial in Germany, it is evaluated as a pre-treatment to improve pregnancy outcomes in women with advanced endometriosis undergoing IVF/ICSI.
- Brand names
- Enantone-Gyn Monats-DepotEnantone
- Other names
- leuprorelin acetateleuprolide acetate
02
Targets
GnRHR (Gonadotropin-releasing hormone receptor)
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