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levamisole + oxyclozanide + cobalt sulphate
- Development stage
- Unknown
- Lead developer
- Sams Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Liversam is a veterinary anthelmintic suspension developed by Sams Pharmaceutical. It is a fixed-dose combination containing levamisole hydrochloride, oxyclozanide, and cobalt sulphate. Levamisole acts as a cholinergic agonist on nematode nicotinic acetylcholine receptors, causing spastic paralysis and expulsion of gastrointestinal roundworms and lungworms. Oxyclozanide is a salicylanilide that uncouples mitochondrial oxidative phosphorylation, specifically targeting adult liver flukes (*Fasciola hepatica*) and rumen flukes (*Paramphistomum*). Cobalt sulphate is included as a nutritional supplement to support vitamin B12 synthesis in ruminants. Liversam is indicated for the treatment and control of mixed endoparasitic infestations in livestock such as cattle, sheep, and goats.
- Brand names
- Liversam
- Other names
- Liversam Suspension
02
Targets
Nicotinic Acetylcholine Receptor
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