Drug intelligence / Profile preview

levofloxacin + prednisolone

Development stage
Unknown
Lead developer
Daiichi Sankyo
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Ophthalmic, Topical
01

Overview

Levofloxacin + prednisolone is a fixed-dose combination drug, most commonly formulated as an ophthalmic solution (eye drops), used to treat bacterial infections of the eye and associated inflammation. Levofloxacin is a third-generation fluoroquinolone antibiotic that acts by inhibiting bacterial DNA gyrase, thereby preventing DNA replication and leading to bacterial cell death. Prednisolone is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory properties; it works by inhibiting the synthesis of pro-inflammatory mediators such as cytokines and prostaglandins. The combination provides both antibacterial action (from levofloxacin) and anti-inflammatory effects (from prednisolone), making it effective for conditions like post-operative endophthalmitis, acute exacerbations of chronic bronchitis with ocular involvement, community-acquired ocular infections, or other inflammatory/infectious diseases of the eye[2][3][5]. This product is typically developed for topical ophthalmic use.

Brand names
LOVEKAP-P
Other names
levofloxacin and prednisolone combination therapylevofloxacin & prednisolone eye drops
02

Targets

Topo IV (Bacterial Topoisomerase IV)DNA gyraseGR (Glucocorticoid receptor)

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