Drug intelligence / Profile preview

lidocaine + bupivacaine + fentanyl

Development stage
Phase 3
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Epidural, Intrathecal
01

Overview

This is a combination of three drugs—lidocaine, bupivacaine, and fentanyl—used primarily for regional anesthesia and analgesia. Lidocaine and bupivacaine are amide-type local anesthetics that block sodium channels in neuronal membranes, inhibiting nerve impulse conduction to provide local or regional numbness. Fentanyl is a potent synthetic opioid agonist at the mu-opioid receptor, providing strong analgesic effects. The combination leverages the rapid onset of lidocaine, the prolonged duration of bupivacaine, and the synergistic pain relief from fentanyl. This mixture may be used in epidural or spinal anesthesia for surgical procedures or labor analgesia to achieve effective pain control with reduced doses of each component[1][2][5][6].

02

Targets

MOR (Mu opioid receptor)NaV alpha (Voltage-gated sodium channel alpha subunit family)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)

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