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lidocaine + esketamine
- Development stage
- Unknown
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Lidocaine + esketamine is an intravenous combination therapy being investigated for the management of postoperative pain and recovery, specifically in patients undergoing liver cancer surgery. Lidocaine is a local anesthetic and anti-arrhythmic that acts as a sodium channel blocker, while esketamine (the S-enantiomer of ketamine) is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with analgesic and anesthetic properties. The combination aims to leverage multimodal analgesia to reduce opioid consumption and improve postoperative outcomes. This specific study is sponsored by West China Hospital, Sichuan University.
- Other names
- lidocaine + S-ketamineintravenous lidocaine and S-ketamine
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)
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