lidocaine + ibuprofen

**Lidocaine + ibuprofen** is a nonspecific two-active analgesic combination that may refer either to separate co-administration of lidocaine and ibuprofen or to a compounded topical preparation containing both agents. Lidocaine is an amide local anesthetic that inhibits voltage-gated sodium-channel-dependent nerve impulse conduction, producing local analgesia or anesthesia. Ibuprofen is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes, reducing prostaglandin production and thereby relieving pain and inflammation. A compounded topical cream containing ibuprofen 10% and lidocaine hydrochloride 5% has been described for localized painful inflammatory conditions, and a clinical study has evaluated a lidocaine patch plus ibuprofen for acute musculoskeletal pain. ([bayviewrx.com](https://www.bayviewrx.com/formulas/Ibuprofen-10-Lidocaine-HCl-5-Topical-Cream-Osteoarthritis-Neuropathic-Pain-Tendinitis-Bursitis-Sprains-and-Strains))

Other names

ibuprofen + lidocainelidocaine-ibuprofen