Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
lidocaine + ketorolac
- Development stage
- Phase 4
- Lead developer
- IT3 Medical
- Modality
- Small Molecules
- Administration
- Intramuscular, Intravenous, Percutaneous, Topical
01
Overview
**Lidocaine + ketorolac** is a non-opioid analgesic combination consisting of lidocaine, an amide local anesthetic, and ketorolac, a nonsteroidal anti-inflammatory drug. Lidocaine inhibits neuronal voltage-gated sodium-channel ion flux to prevent initiation and propagation of nociceptive impulses, while ketorolac reversibly inhibits cyclooxygenase-1 and cyclooxygenase-2, reducing prostaglandin-mediated pain and inflammation. The combination has been administered together in local and regional anesthesia, intravenous regional anesthesia, perioperative analgesia, and procedural pain-management settings. In the United States, IT3 Medical markets co-packaged lidocaine hydrochloride and ketorolac tromethamine kits as Acunistat-30 and Acunistat-60 under abbreviated new drug applications. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fad54f13-52a6-4c4b-9120-46bfffe2808e))
- Brand names
- Acunistat-30Acunistat30Acunistat 30Acunistat-60Acunistat60Acunistat 60
- Other names
- ketorolac + lidocaineketorolac-lidocainelidocaine + ketorolaclidocaine and ketorolaclidocaine hydrochloride + ketorolac tromethaminelidocaine-ketorolaclidocaine/ketorolac
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NaV alpha (Voltage-gated sodium channel alpha subunit family)
Beyond the preview
Go deeper on lidocaine + ketorolac.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on lidocaine + ketorolac.