lidocaine + magnesium

Lidocaine + magnesium is a combination of two agents—lidocaine, an amide-type local anesthetic and antiarrhythmic, and magnesium (typically administered as magnesium sulfate), an essential mineral with neuromodulatory properties. This combination is used intravenously in perioperative settings for multimodal anesthesia or for the management of intractable neuropathic pain. Lidocaine acts primarily by blocking voltage-gated sodium channels on neuronal membranes, stabilizing them and inhibiting the initiation and conduction of nerve impulses. Magnesium exerts analgesic effects mainly through antagonism of N-methyl-D-aspartate (NMDA) receptors, reducing central sensitization to pain. When combined, these drugs have been shown to provide opioid-sparing effects during surgery, improve hemodynamic stability under general anesthesia without prolonging neuromuscular blockade recovery time beyond that caused by magnesium alone, and offer relief in cases of refractory neuropathic pain such as trigeminal neuralgia[1][2][5][8].

Other names

lidocaine and magnesiumlidocaine plus magnesiumlidocaine + magnesium sulfate