Drug intelligence / Profile preview

lidocaine + normal saline

Development stage
Unknown
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Intraarticular, Perineural
01

Overview

Lidocaine + normal saline is a combination therapy being investigated by Sohag University for the management of advanced hip damage in patients with axial spondyloarthritis. This intervention combines hip denervation, achieved through the injection of lidocaine (a local anesthetic), with intra-articular hydration using normal saline. Lidocaine functions by blocking voltage-gated sodium channels, thereby inhibiting the conduction of pain signals from the affected joint. Normal saline is injected into the hip joint to provide mechanical hydration, which may improve joint mobility and reduce friction. This combination is specifically targeted at patients with high BASRI scores (3 and 4) to alleviate pain and improve functional outcomes. The therapy is administered via perineural injection for denervation and intra-articular injection for hydration.

Other names
Combined group-Sohag University-axial spondyloarthritisHip denervation and intra-articular hydration
02

Targets

SCN9A (Sodium channel protein type 9 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)

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