Drug intelligence / Profile preview

lidocaine + oxycodone

Development stage
Preclinical
Lead developer
AstraZeneca
Modality
Small Molecules
Administration
Topical, Transdermal, Subcutaneous, Intramuscular, Epidural, Intrathecal
01

Overview

Lidocaine + oxycodone is a combination drug consisting of lidocaine, a local anesthetic, and oxycodone, an opioid analgesic. Lidocaine works by blocking sodium channels in neuronal cell membranes, thereby inhibiting nerve impulse conduction and producing local or regional anesthesia. Oxycodone acts primarily as an agonist at the mu-opioid receptor in the central nervous system to alter pain perception and response. This combination would theoretically provide both rapid-onset local anesthesia (from lidocaine) and systemic pain relief (from oxycodone), potentially for procedures or conditions requiring both modalities of analgesia[1][6]. However, there is no evidence from the provided sources that this specific combination is marketed under a unique brand name or widely approved as a fixed-dose product.

02

Targets

NaV (Voltage-gated sodium channels)MOR (Mu opioid receptor)

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