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lidocaine + phenazone
- Development stage
- Unknown
- Lead developer
- Biocodex
- Modality
- Small Molecules
- Administration
- Otic
01
Overview
**Lidocaine + phenazone** is a combination otic solution used for symptomatic relief of pain and inflammation in acute otitis media and other ear conditions with intact tympanic membrane. Lidocaine, a local anesthetic of the amide class, blocks sodium channels in neuronal membranes to inhibit nerve signal transmission and numb pain. Phenazone, a pyrazolone derivative and non-steroidal anti-inflammatory drug (NSAID), inhibits prostaglandin synthesis to reduce inflammation, fever, and pain, while also potentiating lidocaine's anesthetic effect through enhanced local bioavailability. Primarily administered as ear drops for otitis media (congestive phase), viral otitis, and barotrauma in children over 6 months and adults; contraindicated in tympanic perforation.[1][2][3][4][9]
- Brand names
- Otipax
- Other names
- phenazone + lidocainelidocaine / lignocaine + phenazone
02
Targets
NaV (Voltage-gated sodium channels)
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