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lidocaine + prilocaine (Centre Hospitalier Universitaire d'Angers)
- Development stage
- Phase 4
- Lead developer
- Centre Hospitalier Universitaire d'Angers
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Lidocaine + prilocaine is a topical anesthetic combination, often marketed under the brand name EMLA, consisting of two amide-type local anesthetics. It functions by stabilizing neuronal membranes through the inhibition of voltage-gated sodium channels, thereby preventing the initiation and conduction of nerve impulses. This specific combination is being utilized by University Hospital, Angers, in clinical studies to assess cutaneous microcirculatory vasomotor reserve. By applying the cream as a chemical stimulus, researchers can evaluate the physiological response of the microvasculature, providing a methodology to investigate microvascular dysfunction in conditions such as diabetes.
- Brand names
- EMLA
- Other names
- lidocaine/prilocainelidocaine-prilocaine
02
Targets
NaV (Voltage-gated sodium channels)
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