lidocaine + vitamin B12

This combination therapy consists of the local anesthetic lidocaine and vitamin B12 (typically in the form of cyanocobalamin or methylcobalamin). It is primarily developed and investigated by researchers at Qilu Hospital of Shandong University for the treatment of chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS). Lidocaine functions as a voltage-gated sodium channel blocker, providing immediate analgesic effects by inhibiting nerve conduction in the pelvic region. Vitamin B12 is included for its neuroprotective properties, aiming to repair damaged nerves and modulate neuropathic pain pathways that contribute to the persistence of CPPS. The treatment is typically administered via local injection, such as transperineal or intraprostatic routes, to provide targeted relief for patients who are refractory to conventional oral medications.

Other names

lidocaine and vitamin B12lidocaine and cyanocobalaminlidocaine and methylcobalamin