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lidocaine hydrochloride + bacitracin zinc + polymyxin b sulfate + neomycin sulfate
- Development stage
- Unknown
- Lead developer
- Kenvue
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Lidocaine hydrochloride + bacitracin zinc + polymyxin b sulfate + neomycin sulfate is an OTC topical combination product that pairs three first-aid antibiotics with a local anesthetic for minor wound care. Bacitracin zinc inhibits bacterial cell-wall synthesis, polymyxin B disrupts the outer membrane of susceptible Gram-negative bacteria, neomycin is an aminoglycoside that inhibits bacterial protein synthesis, and lidocaine blocks voltage-gated sodium channels to provide temporary local analgesia. Publicly verifiable marketed products include **Neosporin Plus Lidocaine** from Kenvue and generic **Triple Antibiotic Plus Lidocaine** ointments from companies such as Trifecta Pharmaceuticals USA and Shandong Teking Pharmaceutical. The labeled use is prevention of infection and temporary relief of pain or discomfort in minor cuts, scrapes, and burns; the provided painful urethritis context appears to reflect confusion with lidocaine hydrochloride jelly rather than this four-ingredient skin ointment.
- Brand names
- Neosporin Plus LidocaineTriple Antibiotic Plus Lidocaine
- Other names
- triple antibiotic ointment + lidocainebacitracin zinc + neomycin sulfate + polymyxin b sulfate + lidocainebacitracin zinc + lidocaine + neomycin sulfate + polymyxin b sulfate
02
Targets
Bacterial RibosomeSCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)Bacterial cell membrane
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