Drug intelligence / Profile preview

lidocaine hydrochloride + bupivacaine hydrochloride + triamcinolone acetonide + povidone-iodine

Development stage
Unknown
Lead developer
Asclemed USA
Modality
Small Molecules
Administration
Parenteral, Topical
01

Overview

This is a multi-component procedural drug kit containing the amide local anesthetics **lidocaine hydrochloride** and **bupivacaine hydrochloride**, the synthetic glucocorticoid **triamcinolone acetonide**, and the topical antiseptic **povidone-iodine**. Lidocaine and bupivacaine reversibly inhibit voltage-gated sodium channels, preventing action-potential propagation and producing local or regional anesthesia and analgesia. Triamcinolone acetonide activates glucocorticoid receptors to suppress inflammatory signaling, while povidone-iodine releases iodine with broad microbicidal activity for skin antisepsis. The exact four-component composition is publicly listed in DailyMed as the unapproved prescription kit products BLT-25 Kit and MLK F4 Kit, packaged by Asclemed USA; their labeling states that the products have not been found by FDA to be safe and effective and that the labeling has not been approved by FDA. ([dailymed.nlm.nih.gov](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=87307801-d970-41cf-ad1e-d89b0ff8549f))

Brand names
BLT-25 KitBLT25 KitBLT 25 KitMLK F4 Kit
Other names
lidocaine hydrochloride + bupivacaine hydrochloride + triamcinolone acetonide + povidine iodine
02

Targets

NaV (Voltage-gated sodium channels)Microbial macromoleculesGR (Glucocorticoid receptor)

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