Drug intelligence / Profile preview

lidocaine hydrochloride + polymyxin b sulfate + bacitracin zinc + neomycin

Development stage
Unknown
Lead developer
Kenvue
Modality
Small Molecules
Administration
Topical
01

Overview

This drug is a **topical fixed-dose combination** of three antibacterial agents and one local anesthetic: bacitracin zinc, neomycin, polymyxin B sulfate, and lidocaine hydrochloride. The antibiotic components provide broad topical antibacterial activity through complementary mechanisms: polymyxin B disrupts the outer membrane of susceptible Gram-negative bacteria, bacitracin inhibits bacterial cell wall synthesis, and neomycin is an aminoglycoside that inhibits bacterial protein synthesis by binding the 30S ribosomal subunit. Lidocaine provides local analgesia by blocking voltage-gated sodium channels in peripheral nerves. Publicly verifiable sources support this combination as an **OTC first-aid ointment** marketed for temporary prevention of infection and relief of pain in minor cuts, scrapes, and burns. Although the supplied context mentions painful urethritis, the identifiable public-source evidence located for this exact four-ingredient combination supports a dermatologic topical ointment product rather than a urethral jelly or a clearly established urethritis-specific development program.

Brand names
Triple Antibiotic Plus Lidocaine
Other names
lidocaine hydrochloride + polymyxin b sulfate + bacitracin zinc + neomycinbacitracin zinc + neomycin sulfate + polymyxin b sulfate + lidocainepolymyxin b sulfate + neomycin sulfate + bacitracin zinc + lidocaine hydrochloride
02

Targets

UPP (Undecaprenyl pyrophosphate)16S ribosomal RNA A-site decoding regionLPS (Lipopolysaccharide and bacterial membrane lipids)NaV (Voltage-gated sodium channels)

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