Drug intelligence / Profile preview

lignocaine + dextrose

Development stage
Unknown
Lead developer
Walker's Pharmaceuticals
Modality
Small Molecules
Administration
Intrathecal, Intravenous, Parenteral
01

Overview

Lignocaine + dextrose (also known as lidocaine and dextrose) is an approved, fixed-dose injectable combination of the local anesthetic and antiarrhythmic agent lignocaine (lidocaine) and dextrose. Developed as a generic life-saving injectable by Walker's Pharmaceuticals, this formulation is primarily utilized for spinal (intrathecal) anesthesia and the management of cardiac arrhythmias. Lignocaine functions as a sodium channel blocker, preventing the initiation and conduction of nerve impulses to produce local anesthesia. The addition of dextrose increases the baricity of the solution, rendering it hyperbaric, which allows for controlled spread and localization of the anesthetic within the spinal canal during intrathecal administration.

Other names
lidocaine + dextroselidocaine and dextroselidocaine hydrochloride & dextroselignocaine & dextroselignocaine & dextrose inj.lignocaine and dextroselignocaine hydrochloride & dextrose
02

Targets

SCN5A (Sodium channel protein type 5 subunit alpha)NaV alpha (Voltage-gated sodium channel alpha subunit family)SCN10A (Sodium channel protein type X alpha subunit)SCN9A (Sodium channel protein type 9 subunit alpha)

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