ligustrazine + ferulic acid acetate

Ligustrazine + ferulic acid acetate is a pharmaceutical combination or conjugate consisting of ligustrazine (tetramethylpyrazine) and ferulic acid acetate (acetylferulic acid), two active compounds derived from traditional Chinese medicinal herbs such as *Ligusticum chuanxiong*. Ligustrazine acts as a calcium channel blocker and vasodilator, inhibiting platelet aggregation and improving microcirculation by reducing calcium influx into vascular smooth muscle cells. Ferulic acid acetate, an acetylated derivative of ferulic acid, serves as a potent antioxidant and anti-platelet agent by inhibiting thromboxane A2 synthase and scavenging free radicals. This combination is primarily investigated for its synergistic effects in treating ischemic cerebrovascular and cardiovascular diseases, including stroke and coronary heart disease, by providing neuroprotection, reducing thrombosis, and mitigating oxidative stress. While the salt form, ligustrazine ferulate, is an approved medication in China, the acetate derivative is frequently used in research to enhance the lipophilicity and pharmacological profile of the parent compounds.

Other names

ligustrazine acetylferulatetetramethylpyrazine + acetylferulic acidligustrazine-ferulic acid acetate conjugate