Drug intelligence / Profile preview

liothyronine + cyclophosphamide + methotrexate + prednisone

Development stage: Unknown
Lead developer: Ipe
Modality: Small Molecules
Administration: Oral, Intravenous, Intramuscular, Intrathecal

Overview

A combination chemotherapy regimen that includes liothyronine (thyroid hormone), cyclophosphamide (alkylating agent), methotrexate (antimetabolite), and prednisone (corticosteroid). This combination may be used in the treatment of certain hematological malignancies. Methotrexate interferes with folate metabolism and DNA synthesis, cyclophosphamide is an alkylating agent that damages DNA, prednisone has anti-inflammatory and immunosuppressive effects, and liothyronine is a thyroid hormone that may be included to address thyroid function.

Targets

GR (Glucocorticoid receptor)DHFR (Dihydrofolate reductase)DNATHR (Thyroid hormone receptor)

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