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liothyronine + sertraline
- Development stage
- Unknown
- Lead developer
- Ipe
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Liothyronine + sertraline is a combination of two pharmaceutical drugs used in clinical research for the treatment of major depressive disorder. Liothyronine (triiodothyronine, T3) is a synthetic form of the thyroid hormone that regulates metabolism and has been investigated as an adjunct to antidepressant therapy. Sertraline is a selective serotonin reuptake inhibitor (SSRI) commonly prescribed for depression. The rationale for combining these agents stems from evidence that thyroid hormones may potentiate or accelerate antidepressant effects. Clinical trials have shown mixed results regarding efficacy; some studies report enhanced response and remission rates when liothyronine is added to sertraline in patients with major depressive disorder, while others do not find significant benefit over monotherapy[1][2][5]. The combination appears generally well tolerated without significant increases in adverse effects compared to monotherapy[1][2][7].
- Brand names
- CytomelZoloft
- Other names
- liothyronine and sertralinetriiodothyronine and sertralineT3 and sertralineT-3 and sertralineT 3 and sertraline
02
Targets
THRB (Thyroid hormone receptor beta)SERT (Sodium-dependent serotonin transporter)THRA (Thyroid hormone receptor alpha)
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