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Liothyronine sodium is a synthetic form of the active thyroid hormone triiodothyronine (T3). Carnegie Pharmaceuticals markets this as an FDA-approved generic oral tablet indicated for replacement or supplemental therapy in hypothyroidism, including primary, secondary, and tertiary forms. The drug functions by binding to nuclear thyroid hormone receptors (TR), specifically TRα and TRβ, mimicking the action of endogenous T3 to regulate metabolic processes and gene expression. It is available in 5 mcg, 25 mcg, and 50 mcg strengths and is used to restore metabolic homeostasis in patients with thyroid hormone deficiencies.
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