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Drug intelligence / Profile preview
liposomal irinotecan + 5-fluorouracil + leucovorin + lenvatinib
- Development stage
- Unknown
- Lead developer
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Oral
01
Overview
This combination chemotherapy and targeted therapy regimen is being evaluated as a second-line treatment for advanced biliary tract cancer. It consists of liposomal irinotecan (a nanoliposomal formulation of the topoisomerase I inhibitor irinotecan), 5-fluorouracil (an antimetabolite), leucovorin (a folate analog that enhances 5-FU activity), and lenvatinib (a multi-kinase inhibitor). The regimen aims to inhibit tumor cell replication through DNA damage and metabolic disruption while simultaneously targeting angiogenesis and tumor growth pathways by inhibiting VEGFR, FGFR, and other receptor tyrosine kinases. It is currently being studied in a Phase II clinical trial sponsored by the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, specifically for patients who have progressed after first-line therapy.
- Other names
- nal-IRI + 5-FU/LV + lenvatinibLiposomal irinotecan II + 5-FU + LV + lenvatinib
02
Targets
TOP1 (DNA Topoisomerase I)FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)RET (Rearranged during transfection receptor tyrosine kinase)TS (Thymidylate synthase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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