liposome bupivacaine (bupivacaine liposome) (Pacira BioSciences, 045428)

Bupivacaine liposome (brand name: Exparel) is a long-acting, extended-release local anesthetic formulation developed by Pacira BioSciences. It utilizes the DepoFoam multivesicular liposomal drug delivery system to encapsulate bupivacaine, a small molecule sodium channel blocker, allowing for controlled release over approximately 72 hours. By inhibiting voltage-gated sodium channels on nerve cell membranes, it prevents the initiation and conduction of nerve impulses, thereby providing prolonged postsurgical analgesia. It is primarily indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block for postsurgical regional analgesia.

Brand names

Exparel

Other names

liposomal bupivacainebupivacaine liposome injectable suspension