liposome bupivacaine (Pacira BioSciences)

Liposome bupivacaine is an extended-release formulation of the amide-type local anesthetic bupivacaine. It utilizes the DepoFoam multivesicular liposomal drug delivery system, which consists of microscopic, lipid-based particles containing numerous non-concentric internal aqueous chambers that encapsulate the drug. This technology allows for a slow, controlled release of bupivacaine over an extended period (up to 72 hours), providing prolonged postsurgical analgesia and potentially reducing the need for opioids. It works by binding to the intracellular portion of voltage-gated sodium channels, blocking sodium influx into nerve cells, which prevents the generation and conduction of nerve impulses. It is primarily indicated for single-dose infiltration in adults to produce postsurgical local analgesia and as an interscalene brachial plexus nerve block. Clinical trials, such as those conducted by the Anhui Women and Children Medical Center, have explored its efficacy in specific settings like cesarean sections.

Brand names

Exparel

Other names

bupivacaine liposome injectable suspensionliposomal bupivacaine