Drug intelligence / Profile preview

liraglutide + metformin + testosterone undecanoate

Development stage
Unknown
Lead developer
Novo Nordisk
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Peptides
Administration
Subcutaneous, Oral, Intramuscular
01

Overview

This is a combination therapy consisting of three active pharmaceutical ingredients: - **Liraglutide** is a glucagon-like peptide 1 (GLP-1) receptor agonist used for glycemic control in type 2 diabetes and for weight management (obesity). It enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon secretion, and slows gastric emptying. - **Metformin** is a biguanide, commonly used as a first-line treatment for type 2 diabetes. Its primary mechanisms involve reducing hepatic glucose production, decreasing intestinal glucose absorption, and improving insulin sensitivity in peripheral tissues, largely through activation of AMP-activated protein kinase (AMPK). - **Testosterone undecanoate** is an androgen and anabolic steroid, used as a prodrug for testosterone replacement therapy, primarily for men with clinical symptoms of hypogonadism. It is converted to testosterone in the body, which then acts on androgen receptors to exert its effects. This combination is not available as a single fixed-dose formulation but rather represents the concomitant administration of three separate approved medications, often for patients with comorbidities such as type 2 diabetes (managed by liraglutide and metformin), concurrent obesity (managed by liraglutide), and hypogonadism (managed by testosterone undecanoate).

02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)ND1 (Mitochondrial electron transport chain complex I)GLP1R (GLP-1R)SLC5A1 (Sodium Glucose Cotransporter 1)AR (Adrenergic receptors)

Beyond the preview

Go deeper on liraglutide + metformin + testosterone undecanoate.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on liraglutide + metformin + testosterone undecanoate.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call