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Liuhe Dan is a traditional Chinese medicine (TCM) topical preparation, typically formulated as an ointment, recognized for its potent anti-inflammatory and analgesic properties. It is primarily developed and utilized by the West China Hospital of Sichuan University, where it serves as a standard external treatment for acute pancreatitis-associated abdominal pain. The formulation is composed of a synergistic blend of herbal ingredients, commonly including *Rheum palmatum* (Dahuang), *Phellodendron amurense* (Huangbai), and *Curcuma longa* (Jianghuang). Its therapeutic mechanism involves the modulation of local inflammatory cytokines and the improvement of microcirculation in the abdominal region when applied topically. Beyond pancreatitis, it is also used in clinical practice for conditions such as phlebitis, mumps, and localized cellulitis.
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