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live attenuated measles vaccine + live attenuated Japanese encephalitis vaccine SA 14-14-2
- Development stage
- Unknown
- Lead developer
- Chengdu Institute of Biological Products
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
This refers to the co-administration of two distinct live attenuated vaccines: the SA 14-14-2 Japanese encephalitis vaccine (LJEV) and a standard measles vaccine. The SA 14-14-2 strain is a live, attenuated virus developed by the Chengdu Institute of Biological Products (CDIBP) to prevent Japanese encephalitis, a mosquito-borne flavivirus infection. The measles vaccine used in the referenced study was produced by the Serum Institute of India. PATH (Program for Appropriate Technology in Health) sponsored a Phase 4 clinical trial in Sri Lanka to evaluate the safety and immunogenicity of administering these two vaccines simultaneously to 9-month-old infants. The study aimed to facilitate the integration of the JE vaccine into national immunization programs by demonstrating that co-administration does not interfere with the immune response to either pathogen.
- Other names
- LJEV and measles vaccine co-administrationSA 14-14-2 JE vaccine + measles vaccine
02
Targets
SLAMF1 (SLAM family member 1)CD46 (CD46 Molecule)IFIH1 (MDA5)PVRL4 (Nectin cell adhesion molecule 4)DDX58 (Retinoic acid-inducible gene I protein)
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