Live Attenuated Yellow Fever 17D Vaccine + Quadrivalent Influenza Vaccine

This entry refers to the co-administration or comparative evaluation of the Live Attenuated Yellow Fever 17D vaccine and the Quadrivalent Influenza Vaccine (QIV) within a clinical research framework at Emory University. The primary objective of this research, often titled "Systems Biological Assessment of the Durability of Vaccine Responses," is to utilize systems biology approaches to compare the long-lasting immunity elicited by the Yellow Fever 17D-204 strain (YF-VAX) with the more transient immunity produced by seasonal quadrivalent influenza vaccines. The study involves administering these FDA-approved vaccines to healthy volunteers and performing high-resolution molecular and cellular analysis of blood, bone marrow, and lymph node samples to identify the determinants of immunological memory. The Yellow Fever component is a live-attenuated virus that induces broad T-cell and B-cell responses, whereas the influenza component is typically an inactivated vaccine containing antigens from four seasonal strains.

Brand names

YF-VAX

Other names

YF-17DYF17DYF 17DQIVSystems Biological Assessment of Vaccine Response Durability