Drug intelligence / Profile preview

LMX-4 (lidocaine)

Development stage
Phase 4
Lead developer
Ferndale Laboratories
Modality
Small Molecules
Administration
Topical
01

Overview

LMX-4 is a topical anesthetic cream containing 4% lidocaine encapsulated in a liposomal delivery system. This formulation is designed to enhance the penetration of lidocaine through the skin's stratum corneum, allowing for rapid and effective local anesthesia. It is primarily indicated for minor dermatological procedures, such as venipuncture, intravenous cannulation, and laser treatments, typically requiring an application time of 15 to 40 minutes. By blocking voltage-gated sodium channels in the neuronal membrane, lidocaine inhibits the initiation and conduction of nerve impulses, thereby providing temporary relief from pain. LMX-4 was originally developed by Ferndale Laboratories and was previously marketed under the brand name Ela-Max.

Brand names
LMX-4LMX4LMX 4Ela-Max
Other names
liposomal lidocaine 4%lidocaine 4% cream
02

Targets

SCN10A (Sodium channel protein type X alpha subunit)SCN11A (NaV1.9)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN3A (Sodium channel protein type 3 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)SCN9A (Sodium channel protein type 9 subunit alpha)SCN8A (NaV1.6)

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