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lobaplatin + ethiodized poppyseed oil
- Development stage
- Unknown
- Lead developer
- Guangxi Medical University
- Modality
- Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intra-arterial
01
Overview
lobaplatin + ethiodized poppyseed oil is a chemoembolic combination therapy being evaluated by Guangxi Medical University for the adjuvant treatment of hepatocellular carcinoma (HCC). The regimen involves the intra-arterial administration of lobaplatin, a third-generation platinum derivative, emulsified with ethiodized poppyseed oil (also known as Lipiodol). The ethiodized oil serves a dual purpose: it acts as a radio-opaque contrast agent for imaging and as a drug delivery vehicle that selectively accumulates in the hypervascular environment of HCC tumors. Once deposited, the oil provides a temporary embolic effect, while the lobaplatin induces tumor cell death by forming DNA cross-links and inhibiting DNA synthesis. This specific combination is currently in Phase III clinical trials as a postoperative adjuvant therapy to reduce recurrence rates in patients who have undergone curative hepatectomy for HCC with high-risk factors.
- Brand names
- LipiodolEthiodolLobap
- Other names
- ethiodized poppyseed oiliodized oilethiodized oilLipiodol Ultra-Fluidlobaplatin
02
Targets
DNA
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