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lobeglitazone + glimepiride
- Development stage
- Unknown
- Lead developer
- Chong Kun Dang Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Lobeglitazone + glimepiride is an **oral fixed-dose combination anti-diabetic medication** used for the management of type 2 diabetes mellitus. **Lobeglitazone** is a thiazolidinedione-class insulin sensitizer that selectively activates peroxisome proliferator-activated receptor gamma (PPARγ), enhancing insulin sensitivity in adipose tissue and muscle. **Glimepiride** is a sulfonylurea-class insulin secretagogue that stimulates insulin release from pancreatic beta cells by binding to ATP-sensitive potassium channels, leading to cell depolarization and insulin exocytosis. This dual mechanism addresses both insulin resistance and insufficient insulin secretion, resulting in improved glycemic control for patients unresponsive to monotherapy. The combination is taken orally, typically once daily, and is primarily indicated for adults with type 2 diabetes mellitus[1][4][5].
- Other names
- lobeglitazone sulfate + glimepiridelobeglitazone sulfate + glimepiride fixed-dose combination
02
Targets
PTPN1 (Protein tyrosine phosphatase 1B)KATP channel (ATP-sensitive potassium channel)PPARG (Peroxisome proliferator-activated receptor gamma)PPARA (Peroxisome proliferator-activated receptor alpha)
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