lobeglitazone + metformin

**Lobeglitazone + metformin** is an oral fixed-dose antidiabetic combination marketed in South Korea as **Duvimet XR** for adults with type 2 diabetes mellitus whose glycemic control requires concomitant lobeglitazone and metformin. Lobeglitazone is a thiazolidinedione insulin sensitizer and peroxisome proliferator-activated receptor gamma agonist, while metformin is a biguanide that reduces hepatic glucose production and activates AMP-activated protein kinase signaling. CKD-395 pharmacokinetic studies found exposure comparable with concomitant administration of the individual agents; the marketed product uses an extended-release metformin formulation. ([ckdpharm.com](https://ckdpharm.com/en/product/productView.do?prodCode=CKD0000428))

Brand names

Duvimet XR

Other names

lobeglitazone sulfate + metformin hydrochloridemetformin + lobeglitazone