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local anesthetics + corticosteroids
- Development stage
- Unknown
- Lead developer
- Zagazig University
- Modality
- Small Molecules
- Administration
- Perineural Injection
01
Overview
This refers to a combination therapy consisting of local anesthetics and corticosteroids administered via supratrochlear and greater occipital nerve block injections. This specific treatment protocol is being evaluated by **Zagazig University** in a randomized controlled trial (NCT06684249) for the management of chronic migraine in adults, comparing its efficacy to Botulinum toxin A (Botox). Local anesthetics work by blocking voltage-gated sodium channels on peripheral sensory nerves to inhibit pain signal transmission, while corticosteroids provide anti-inflammatory effects that may prolong the duration of the analgesic block. The treatment is typically administered once every 12 weeks.
- Other names
- Nerve Block InjectionsSupratrochlear and Greater Occipital Nerve Blocks
02
Targets
GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)
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