lofexidine + buprenorphine

Lofexidine + buprenorphine is a **combination of two pharmaceutical agents**: lofexidine, an alpha-2 adrenergic receptor agonist approved for mitigation of opioid withdrawal symptoms, and buprenorphine, a partial opioid agonist approved for opioid use disorder (OUD) maintenance and withdrawal management. The combination is being studied, especially as adjunct therapy, for the treatment of opioid withdrawal and opioid use disorder, sometimes with the goal of also improving post-traumatic stress disorder (PTSD) symptoms. Lofexidine acts by stimulating alpha-2A and alpha-2C adrenoreceptors, resulting in reduced sympathetic outflow and mitigation of withdrawal symptoms without opioid receptor activation. Buprenorphine works primarily as a partial agonist at the mu-opioid receptor, reducing withdrawal symptoms and cravings associated with opioid cessation while lowering potential for misuse compared to full agonists. The combination is not an approved product but is under clinical investigation as an adjunct or parallel therapy in opioid use disorder and PTSD.

Other names

Lofexidine Combined With Buprenorphine