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lomustine + mebendazole
- Development stage
- Unknown
- Lead developer
- NextSource Biotechnology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of lomustine (CCNU), an alkylating agent of the nitrosourea type, and mebendazole, a repurposed antiparasitic drug. Lomustine interferes with DNA and RNA function by damaging the DNA in cancer cells, while mebendazole has demonstrated anticancer activity through tubulin binding, preventing tubulin polymerization. This combination has been investigated primarily for the treatment of recurrent high-grade gliomas, including glioblastoma.
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNA
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