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lonafarnib + ritonavir + peginterferon alfa-2a
- Development stage
- Unknown
- Lead developer
- Eiger BioPharmaceuticals
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Oral, Subcutaneous
01
Overview
**lonafarnib + ritonavir + peginterferon alfa-2a** is a combination antiviral regimen explored for the treatment of viral hepatitis, particularly in chronic hepatitis D virus (HDV) infection. Lonafarnib is a synthetic farnesyltransferase inhibitor that disrupts viral assembly by inhibiting protein prenylation. Ritonavir is a small-molecule inhibitor of HIV protease, used here primarily as a pharmacokinetic booster to increase lonafarnib plasma levels by inhibiting CYP3A metabolism. Peginterferon alfa-2a is a recombinant, pegylated interferon which activates type I interferon receptors, upregulating the JAK/STAT pathway and driving innate antiviral responses. Studies demonstrate that this triple regimen achieves synergistic antiviral effects and enhanced reductions in HDV RNA compared to lonafarnib and ritonavir alone, with most robust responses observed when peginterferon alfa-2a is included[1].
- Other names
- LNFRTVPEG-IFNαPEG-IFNα-2a
02
Targets
CYP3A7 (Cytochrome P450 3A7)FTase (Protein Farnesyltransferase)IFNAR2 (Interferon alpha/beta receptor subunit 2)IFNAR1 (Interferon alpha/beta receptor 1)
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