lorazepam + viqualine

Lorazepam + viqualine is a combination of two psychoactive drugs, each with distinct mechanisms of action. Lorazepam is a benzodiazepine used primarily for the short-term relief of anxiety symptoms and as an adjunct in depressive disorders. It acts as a positive allosteric modulator at the benzodiazepine site of the GABA-A receptor, enhancing inhibitory neurotransmission in the central nervous system[2][6]. Viqualine is an investigational antidepressant and anxiolytic that was never marketed; it functions as both a potent serotonin releasing agent (SRA) and serotonin reuptake inhibitor (SRI), while also exhibiting diazepam-like effects by acting as a positive allosteric modulator at the benzodiazepine site on GABA-A receptors[4][3]. The combination has been studied in treatment-resistant depression, where both agents were administered together to evaluate efficacy and tolerability[1][3].