Drug intelligence / Profile preview

lornoxicam + paracetamol + thiocochicoside

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

This drug is a fixed-dose combination of three active pharmaceutical ingredients: - **Lornoxicam** is a non-steroidal anti-inflammatory drug (NSAID) from the oxicam class, which works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. - **Paracetamol** (also known as acetaminophen) is an analgesic and antipyretic that acts primarily in the central nervous system to inhibit prostaglandin synthesis, providing pain relief and fever reduction. - **Thiocochicoside** is a muscle relaxant that acts on the central nervous system, likely through modulation of GABA-A receptors or glycine receptors, leading to reduced muscle spasms. The combination provides multimodal management for musculoskeletal pain conditions by addressing inflammation, nociceptive pain, and muscle spasm. It is typically used for acute painful musculoskeletal disorders such as back pain, sprains, joint pain with associated muscle spasm, arthritis flare-ups with significant muscular involvement, or post-operative musculoskeletal discomfort.

02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Glycine receptorGABRR (GABA-A receptor subunit rho)PGHS-1 (Prostaglandin G/H Synthase 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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